Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from either insufficient insulin production by the pancreas or an impaired response to insulin by the body’s cells. The condition significantly impacts the metabolism of carbohydrates, fats, and proteins, leading to various long-term complications (Diabetes - WHO).
The prevalence of diabetes worldwide has exceeded 800 million adults, quadrupling since 1990, according to a study in The Lancet by the NCD Risk Factor Collaboration with WHO support. The global diabetes prevalence among adults rose from 7% to 14% between 1990 and 2022, with the largest increases and treatment gaps occurring in low- and middle-income countries (LMICs). Nearly 450 million adults with diabetes remained untreated in 2022, 90% of whom live in LMICs. Regions like South-East Asia, Eastern Mediterranean, and Africa face the lowest treatment coverage, with fewer than 40% of adults receiving medication.
Type 1 Diabetes: An autoimmune condition where the immune system attacks insulin-producing beta cells in the pancreas. This results in little to no insulin production, necessitating lifelong insulin therapy.
Type 2 Diabetes: A condition characterized by insulin resistance and relative insulin deficiency. It is often associated with obesity, sedentary lifestyles, and genetic predisposition.
Gestational Diabetes: This occurs during pregnancy when hormonal changes lead to insulin resistance. While it typically resolves postpartum, it increases the risk of developing type 2 diabetes later in life.
Type 1.5 Diabetes: Also known as latent autoimmune diabetes in adults (LADA), this condition occurs in adulthood and progresses gradually. It is an autoimmune disease and often misdiagnosed as type 2 diabetes but requires insulin therapy.
Prediabetes: A condition where blood sugar levels are higher than normal but not high enough for a diabetes diagnosis. Prediabetes can lead to type 2 diabetes without lifestyle modifications.
A rare condition called diabetes insipidus, unrelated to diabetes mellitus, occurs when the kidneys remove excessive fluid from the body, leading to dehydration and other issues.
III. Risk Factors for Diabetes
A variety of factors contribute to an individual's risk of developing diabetes, influencing the likelihood of complications and the management of the condition.
General Risk Factors
Gender: Men are generally more likely to have diabetes than women. However, socioeconomic factors, such as income, education level, and employment status, impact diabetes rates differently among men and women.
Socioeconomic Disadvantage: Populations with lower socioeconomic status are at higher risk due to contributing factors like:
Obesity
Cigarette smoking
High blood pressure
Prediabetes
You're at a higher risk of developing prediabetes if you have:
Abdominal obesity
A family history of type 2 diabetes
Taking steps to lower your risk and manage blood glucose levels can help prevent or delay the onset of type 2 diabetes.
Type 1 Diabetes
The risk factors for type 1 diabetes are not fully understood but may include:
Fasting Blood Glucose Test: Measures blood sugar after fasting for 8 hours (≥126 mg/dL indicates diabetes).
Oral Glucose Tolerance Test (OGTT): Checks blood sugar levels before and two hours after drinking a glucose solution (≥200 mg/dL confirms diabetes).
HbA1c Test: Reflects average blood sugar levels over 2-3 months (≥6.5% indicates diabetes).
Gestational diabetes is diagnosed through glucose challenge and glucose tolerance tests performed during the second trimester.
VI. Diabetes Complications
Poorly managed diabetes can lead to complications such as:
Cardiovascular Disease: Increased risk of heart attacks and strokes.
Kidney Damage (Nephropathy): Progressing to chronic kidney disease.
Nerve Damage (Neuropathy): Pain, tingling, or numbness in extremities.
Eye Damage (Retinopathy): Potential blindness.
Foot Complications: Ulcers and infections, sometimes requiring amputation.
Pregnancy Complications: High birth weight, premature birth, or increased risk of type 2 diabetes in offspring.
VII. Treatment of Diabetes
Insulin, Medicines, & Other Diabetes Treatments
Taking insulin or other diabetes medicines is often part of treating diabetes. In addition to making healthy food and beverage choices, getting physical activity, getting enough sleep, and managing stress, medicines can help you manage the disease. Some other treatment options are also available.
Read more about Insulin and how to use it here (dẫn link bài viết Insulin)
What Medicines Might I Take for Diabetes?
The medicine you take depends on the type of diabetes you have and how well the medicine controls your blood glucose levels. Other factors, such as your other health conditions, medication costs, and lifestyle, may influence your treatment plan.
What Type of Diabetes Do I Have?
Type 1 Diabetes: Requires insulin therapy because the pancreas does not produce insulin. Insulin delivery options include syringes, pens, pumps, and artificial pancreas systems.
Type 2 Diabetes: Managed with lifestyle changes, oral medications, and sometimes insulin. Insulin may be necessary during specific situations like pregnancy or hospital stays.
Gestational Diabetes: Treated through diet, exercise, and possibly insulin to keep blood glucose levels within a healthy range during pregnancy.
Oral Medicines for Type 2 Diabetes
Oral medications like metformin help reduce blood glucose levels and improve insulin sensitivity.
S/N
Drug Class
Example of Drugs
Adverse Effects
1
Insulin and analogues
Regular Insulin
Hypoglycemia, Weight gain, Insulin allergy, Lipodystrophy at injection sites
2
Sulphonylureas
Glibenclamide
Hypoglycemia, Weight gain, Cardiovascular risk, Rash, Cholestatic jaundice, Bone marrow damage, Photosensitivity
3
Meglitinides
Repaglinide
Hypoglycemia, Sensitivity reactions
4
Biguanides
Metformin
Gastrointestinal effects, Lactic acidosis
5
GLP-1 agonists
Exenatide
Gastrointestinal effects, Pancreatitis, Risks for cancer and cardiovascular events
6
DPP-4 inhibitors
Saxagliptin
Pancreatitis, Risk for cancer, Acute hepatitis, Kidney impairment
7
Thiazolidinedions
Pioglitazone
Hepatitis, Cardiovascular risk, Bladder cancer, Water retention, Weight gain
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